Reactome | Uptake of dietary cobalamins into enterocytes

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Uptake of dietary cobalamins into enterocytes Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
created	[InstanceEdit:9758882] D'Eustachio, Peter, 2021-11-26
dbId	9758881
displayName	Uptake of dietary cobalamins into enterocytes
edited	[InstanceEdit:9758882] D'Eustachio, Peter, 2021-11-26
eventOf	[Pathway:R-HSA-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25562] cobalamin transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3132759] TCN1 binds RCbl - Homo sapiens [BlackBoxEvent:R-HSA-3132753] Pancreatic proteases degrade TCN1:RCbl - Homo sapiens [Reaction:R-HSA-3000120] CBLIF binds RCbl - Homo sapiens [Reaction:R-HSA-3000103] CUBN:AMN binds CBLIF:RCbl - Homo sapiens [BlackBoxEvent:R-HSA-3000137] CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome - Homo sapiens [BlackBoxEvent:R-HSA-3000243] Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl - Homo sapiens [Reaction:R-HSA-5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:9758714] Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking [LiteratureReference:3132773] Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway [LiteratureReference:3132752] Advances in the understanding of cobalamin assimilation and metabolism
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Uptake of dietary cobalamins into enterocytes
orthologousEvent	[Pathway:R-DDI-9758881] Uptake of dietary cobalamins into enterocytes - Dictyostelium discoideum [Pathway:R-DME-9758881] Uptake of dietary cobalamins into enterocytes - Drosophila melanogaster [Pathway:R-GGA-9758881] Uptake of dietary cobalamins into enterocytes - Gallus gallus [Pathway:R-XTR-9758881] Uptake of dietary cobalamins into enterocytes - Xenopus tropicalis [Pathway:R-DRE-9758881] Uptake of dietary cobalamins into enterocytes - Danio rerio [Pathway:R-SSC-9758881] Uptake of dietary cobalamins into enterocytes - Sus scrofa [Pathway:R-BTA-9758881] Uptake of dietary cobalamins into enterocytes - Bos taurus [Pathway:R-CFA-9758881] Uptake of dietary cobalamins into enterocytes - Canis familiaris [Pathway:R-RNO-9758881] Uptake of dietary cobalamins into enterocytes - Rattus norvegicus [Pathway:R-MMU-9758881] Uptake of dietary cobalamins into enterocytes - Mus musculus
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9764895] Hill, David P, 2022-02-14
revised	[InstanceEdit:9759628] D'Eustachio, Peter, 2021-12-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9758881
summation	[Summation:9758883] The steps of transport of dietary cobalamins through the dig...
updateTrackers	[UpdateTracker:9842299] Update Tracker - [Pathway:9758881] Uptake of dietary cobalamins into enterocytes - v86:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9842299] Update Tracker - [Pathway:9758881] Uptake of dietary cobalamins into enterocytes - v86:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism

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