Reactome | Uptake of dietary cobalamins into enterocytes

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100987
displayName	Uptake of dietary cobalamins into enterocytes
eventOf	[Pathway:R-MMU-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:25562] cobalamin transport
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-3000120] CBLIF binds RCbl - Mus musculus [Reaction:R-MMU-5223313] ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells) - Mus musculus
inferredFrom	[Pathway:R-HSA-9758881] Uptake of dietary cobalamins into enterocytes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Uptake of dietary cobalamins into enterocytes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9758881
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-196741] Cobalamin (Cbl, vitamin B12) transport and metabolism
(inferredTo)	[Pathway:R-HSA-9758881] Uptake of dietary cobalamins into enterocytes

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