Reactome | KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2

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KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 Show undefined attributes

authored	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
catalystActivity	[CatalystActivity:8932320] ubiquitin protein ligase activity of KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755506] Rothfels, Karen, 2021-10-08
dbId	9755505
deleted	[Deleted:9768286] Deletion of instance: 8932351
displayName	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
edited	[InstanceEdit:9755510] Rothfels, Karen, 2021-10-08
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens [Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-9755507] UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex - Homo sapiens
input	[Complex:R-HSA-8932286] KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932282] The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase [LiteratureReference:8932330] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 [LiteratureReference:9708494] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
orthologousEvent	[Reaction:R-PFA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Plasmodium falciparum [Reaction:R-DDI-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Dictyostelium discoideum [Reaction:R-CEL-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Caenorhabditis elegans [Reaction:R-DME-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Drosophila melanogaster [Reaction:R-GGA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Gallus gallus [Reaction:R-XTR-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Xenopus tropicalis [Reaction:R-DRE-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Danio rerio [Reaction:R-SSC-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Sus scrofa [Reaction:R-BTA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Bos taurus [Reaction:R-CFA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Canis familiaris [Reaction:R-RNO-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Rattus norvegicus [Reaction:R-MMU-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Mus musculus
output	[Complex:R-HSA-9755498] ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
precedingEvent	[Reaction:R-HSA-8932327] NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 - Homo sapiens
regulatedBy	[NegativeRegulation:9708559] Negative regulation by 'ROS [cytosol]' [NegativeRegulation:9766577] Negative regulation by 'NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]'
regulationReference	[RegulationReference:9708498] Negative regulation by 'ROS [cytosol]' Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex [RegulationReference:9766578] Negative regulation by 'NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]' Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9755505
summation	[Summation:8932313] The KEAP1:CUL3:RBX1 E3-ubiquitin ligase complex is a negativ...

Referrals

(replacementInstances)	[Deleted:9768286] Deletion of instance: 8932351
(hasEvent)	[Pathway:R-HSA-8951664] Neddylation [Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway
(precedingEvent)	[Reaction:R-HSA-9755507] UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex

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