Reactome | KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2

KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2

Stable Identifier

R-HSA-9755505

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2

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The KEAP1:CUL3:RBX1 E3-ubiquitin ligase complex is a negative regulator of Nuclear factor erythroid 2-related (NFE2L2). In the absence of oxidative alterations this E3-ubiquitin ligase complex is bound to NFE2L2 and targets it for ubiquitination (Cullinan et al, 2004; Kobayashi et al, 2004; reviewed in Baird and Yamamoto, 2020).

Literature References

PubMed ID	Title	Journal	Year
32284348	The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway Yamamoto, M, Baird, L	Mol Cell Biol	2020
15282312	Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Yamamoto, M, Kang, MI, Kobayashi, A, Igarashi, K, Chiba, T, Okawa, H, Zenke, Y, Ohtsuji, M	Mol. Cell. Biol.	2004
15367669	The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase Jin, J, Harper, JW, Gordan, JD, Diehl, JA, Cullinan, SB	Mol. Cell. Biol.	2004