Reactome | Negative regulation by 'NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]'

Schema > NegativeRegulation > Entries

activeUnit	[DefinedSet:R-ALL-9714134] NFE2L2 inducers [cytosol]
created	[InstanceEdit:9766576] Rothfels, Karen, 2022-02-22
dbId	9766577
displayName	Negative regulation by 'NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]'
regulatedEntity	[Reaction:R-HSA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 - Homo sapiens
regulator	[Complex:R-HSA-9712276] NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]
schemaClass	NegativeRegulation

(regulation)	[RegulationReference:9766578] Negative regulation by 'NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol]' Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex
(regulatedBy)	[Reaction:R-HSA-9755505] KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2

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