Reactome | ADA deamidates RBV

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ADA deamidates RBV Show undefined attributes

authored	[InstanceEdit:9755068] Stephan, Ralf, 2021-09-20
catalystActivity	[CatalystActivity:9754936] deaminase activity of ADA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9755067] Stephan, Ralf, 2021-10-05
dbId	9754964
displayName	ADA deamidates RBV
edited	[InstanceEdit:9767894] Stephan, Ralf, 2022-03-02
eventOf	[Pathway:R-HSA-9755088] Ribavirin ADME - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [ChemicalDrug:R-ALL-9680963] RBV [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9754918] The relationship between the metabolism of ribavirin and its proposed mechanism of action [LiteratureReference:9754927] Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ADA deamidates RBV
orthologousEvent	[Reaction:R-PFA-9754964] ADA deamidates RBV - Plasmodium falciparum [Reaction:R-DDI-9754964] ADA deamidates RBV - Dictyostelium discoideum [Reaction:R-CEL-9754964] ADA deamidates RBV - Caenorhabditis elegans [Reaction:R-GGA-9754964] ADA deamidates RBV - Gallus gallus [Reaction:R-XTR-9754964] ADA deamidates RBV - Xenopus tropicalis [Reaction:R-DRE-9754964] ADA deamidates RBV - Danio rerio [Reaction:R-SSC-9754964] ADA deamidates RBV - Sus scrofa [Reaction:R-BTA-9754964] ADA deamidates RBV - Bos taurus [Reaction:R-CFA-9754964] ADA deamidates RBV - Canis familiaris [Reaction:R-RNO-9754964] ADA deamidates RBV - Rattus norvegicus [Reaction:R-MMU-9754964] ADA deamidates RBV - Mus musculus
output	[SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-9755025] RBV-COOH [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9755078] NT5C2 tetramer dephosphorylates RBV-MP - Homo sapiens [Reaction:R-HSA-9754934] SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9793976] Thorn, Caroline, 2022-06-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9754964
summation	[Summation:9754943] Ribavirin (RBV) undergoes hydrolytic deamination to its carb...

Referrals

(hasEvent)

[Pathway:R-HSA-9755088] Ribavirin ADME