Reactome | ADA deamidates RBV

ADA deamidates RBV

Stable Identifier

R-HSA-9754964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Ribavirin (RBV) undergoes hydrolytic deamination to its carboxylic acid derivative (RBV-COOH, ICN3297), which does not possess any antiviral activity. The reaction is catalyzed by adenosine deaminase (ADA). As the amount of detectable RBV-COOH is low, deamination is not important in RBV catabolism (Miller et al, 1977; Wu et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12499231	Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions Walker, H, Wu, JZ, Lau, JY, Hong, Z	Antimicrob Agents Chemother	2003
280136	The relationship between the metabolism of ribavirin and its proposed mechanism of action Simon, LN, Kigwana, LJ, Roboz, J, Miller, JP, Robins, RK, Streeter, DG	Ann N Y Acad Sci	1977