Reactome | ADA deamidates RBV

ADA deamidates RBV

Stable Identifier

R-HSA-9754964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ribavirin (RBV) undergoes hydrolytic deamination to its carboxylic acid derivative (RBV-COOH, ICN3297), which does not possess any antiviral activity. The reaction is catalyzed by adenosine deaminase (ADA). As the amount of detectable RBV-COOH is low, deamination is not important in RBV catabolism (Miller et al, 1977; Wu et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
12499231	Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions Wu, JZ, Walker, H, Lau, JY, Hong, Z	Antimicrob Agents Chemother	2003
280136	The relationship between the metabolism of ribavirin and its proposed mechanism of action Miller, JP, Kigwana, LJ, Streeter, DG, Robins, RK, Simon, LN, Roboz, J	Ann N Y Acad Sci	1977