ADA deamidates RBV

Stable Identifier
R-HSA-9754964
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Ribavirin (RBV) undergoes hydrolytic deamination to its carboxylic acid derivative (RBV-COOH, ICN3297), which does not possess any antiviral activity. The reaction is catalyzed by adenosine deaminase (ADA). As the amount of detectable RBV-COOH is low, deamination is not important in RBV catabolism (Miller et al, 1977; Wu et al, 2003).
Literature References
PubMed ID Title Journal Year
12499231 Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions

Walker, H, Wu, JZ, Lau, JY, Hong, Z

Antimicrob Agents Chemother 2003
280136 The relationship between the metabolism of ribavirin and its proposed mechanism of action

Simon, LN, Kigwana, LJ, Roboz, J, Miller, JP, Robins, RK, Streeter, DG

Ann N Y Acad Sci 1977
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Catalyst Activity

deaminase activity of ADA [cytosol]

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