Reactome | GABRR pentamers:GABA transports extracellular Cl- to cytosol

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GABRR pentamers:GABA transports extracellular Cl- to cytosol Show undefined attributes

authored	[InstanceEdit:975450] Jassal, Bijay, 2010-09-24
catalystActivity	[CatalystActivity:975455] chloride channel activity of GABRR pentamers:GABA [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:975450] Jassal, Bijay, 2010-09-24
crossReference	[DatabaseIdentifier:12667891] RHEA:29823
dbId	975449
displayName	GABRR pentamers:GABA transports extracellular Cl- to cytosol
edited	[InstanceEdit:975450] Jassal, Bijay, 2010-09-24
eventOf	[Pathway:R-HSA-977443] GABA receptor activation - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:975453] Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina [LiteratureReference:975456] Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4 [LiteratureReference:975434] Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3 [LiteratureReference:1013810] A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GABRR pentamers:GABA transports extracellular Cl- to cytosol
orthologousEvent	[Reaction:R-CEL-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Caenorhabditis elegans [Reaction:R-DME-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Drosophila melanogaster [Reaction:R-GGA-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Gallus gallus [Reaction:R-XTR-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Xenopus tropicalis [Reaction:R-DRE-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Danio rerio [Reaction:R-SSC-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Sus scrofa [Reaction:R-BTA-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Bos taurus [Reaction:R-CFA-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Canis familiaris [Reaction:R-RNO-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Rattus norvegicus [Reaction:R-MMU-975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol]
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1014332] He, Lei, 2010-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-975449
summation	[Summation:975437] GABA A (rho) receptors are highly expressed in the retina an...
updateTrackers	[UpdateTracker:9787673] Update Tracker - [Reaction:975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - v44:[modifyText] [UpdateTracker:9778655] Update Tracker - [Reaction:975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - v68:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787673] Update Tracker - [Reaction:975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - v44:[modifyText] [UpdateTracker:9778655] Update Tracker - [Reaction:975449] GABRR pentamers:GABA transports extracellular Cl- to cytosol - v68:[modifyText]
(hasEvent)	[Pathway:R-HSA-977443] GABA receptor activation

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