GABRR pentamers:GABA transports extracellular Cl- to cytosol

Stable Identifier
R-HSA-975449
Type
Reaction
Species
Homo sapiens
Compartment
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GABA A (rho) receptors are highly expressed in the retina and are functional homopentamers of rho subunits. These receptors were formerly called GABA C receptors.

The GABA(A)-rho receptor (GABRR) is expressed in many areas of the brain, but in contrast to other GABA(A) receptors, has especially high expression in the retina. It is functional as a homopentamer and is permeable to chloride ions when GABA binds to it (Cutting et al. 1991, Cutting et al. 1992, Bailey et al. 1990).

Literature References
PubMed ID Title Journal Year
1315307 Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4

Seldin, MF, Uhl, GR, O'Hara, B, Curristin, S, Zoghbi, H, Cutting, GR

Genomics 1992
17398006 A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance

Ripps, H, Qian, H, Zhu, Y

Neurosci Lett 2007
10542332 Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3

Darlison, MG, Bailey, ME, Albrecht, BE, Johnson, KJ

Biochim Biophys Acta 1999
1849271 Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina

O'Hara, BF, Kasch, LM, Antonarakis, SE, Uhl, GR, Donovan, DM, Cutting, GR, Guggino, WB, Shimada, S, Montrose-Rafizadeh, C, Lu, L

Proc Natl Acad Sci U S A 1991
Participants
Output
Participates
Catalyst Activity

chloride channel activity of GABRR pentamers:GABA [plasma membrane]

Orthologous Events
Cross References
Rhea
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