GABA A (rho) receptors are highly expressed in the retina and are functional homopentamers of rho subunits. These receptors were formerly called GABA C receptors.
The GABA(A)-rho receptor (GABRR) is expressed in many areas of the brain, but in contrast to other GABA(A) receptors, has especially high expression in the retina. It is functional as a homopentamer and is permeable to chloride ions when GABA binds to it (Cutting et al. 1991, Cutting et al. 1992, Bailey et al. 1990).
Seldin, MF, Uhl, GR, O'Hara, B, Curristin, S, Zoghbi, H, Cutting, GR
Ripps, H, Qian, H, Zhu, Y
Darlison, MG, Bailey, ME, Albrecht, BE, Johnson, KJ
O'Hara, BF, Kasch, LM, Antonarakis, SE, Uhl, GR, Donovan, DM, Cutting, GR, Guggino, WB, Shimada, S, Montrose-Rafizadeh, C, Lu, L
chloride channel activity of GABRR pentamers:GABA [plasma membrane]
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