Reactome | CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly

Schema > Reaction > Entries

CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly Show undefined attributes

authored	[InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
catalystActivity	[CatalystActivity:1258416] carboxypeptidase activity of CNDP2:2Mn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
dbId	9753632
displayName	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly
edited	[InstanceEdit:9753631] Jassal, Bijay, 2021-09-10
eventOf	[Pathway:R-HSA-9753281] Paracetamol ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9753676] NAT1,2 acetylate APAP-Cys to APAP-Mer - Homo sapiens [Reaction:R-HSA-9753284] ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-9753680] APAP-CysGly [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1258418] Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly
orthologousEvent	[Reaction:R-SCE-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Saccharomyces cerevisiae [Reaction:R-SPO-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Schizosaccharomyces pombe [Reaction:R-DDI-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Dictyostelium discoideum [Reaction:R-CEL-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Caenorhabditis elegans [Reaction:R-DME-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Drosophila melanogaster [Reaction:R-GGA-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Gallus gallus [Reaction:R-XTR-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Xenopus tropicalis [Reaction:R-DRE-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Danio rerio [Reaction:R-SSC-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Sus scrofa [Reaction:R-BTA-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Bos taurus [Reaction:R-CFA-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Canis familiaris [Reaction:R-RNO-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Rattus norvegicus [Reaction:R-MMU-9753632] CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly - Mus musculus
output	[SimpleEntity:R-ALL-9753653] APAP-Cys [cytosol] [SimpleEntity:R-ALL-29424] Gly [cytosol]
precedingEvent	[Reaction:R-HSA-9753634] GGT dimers hydrolyse APAP-SG - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9756301] Huddart, Rachel, 2021-10-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9753632
summation	[Summation:9753664] Cytosolic, non-specific peptidase (CNDP2) can hydrolyse cyst...

Referrals

(hasEvent)	[Pathway:R-HSA-9753281] Paracetamol ADME
(precedingEvent)	[Reaction:R-HSA-9753676] NAT1,2 acetylate APAP-Cys to APAP-Mer [Reaction:R-HSA-9753284] ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region