Reactome | CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly

CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly

Stable Identifier

R-HSA-9753632

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CNDP2:2Mn2+ dimer hydrolyses APAP-CysGly

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Cytosolic, non-specific peptidase (CNDP2) can hydrolyse cysteinylglycine (CysGly) to release cysteine (L-Cys) and glycine (Gly) (Tuefel et al. 2003). CNDP2 is functional as a homodimer and is thought to require 2 Mn2+ ions per subunit.

Literature References

PubMed ID	Title	Journal	Year
12473676	Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase Laucher, V, Ledig, JP, Cairns, NJ, Ganzhorn, AJ, Guenet, C, Sauvage, C, Carter, C, Carreau, A, Teufel, M, Smirnova, T, Bernhardt, A, Heintzelmann, B, Boularand, S, Duverger, D, Cowley, DJ, Saudek, V	J Biol Chem	2003