Signaling by RAS GTPase mutants

Stable Identifier
R-HSA-9753512
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signaling by RAS GTPase mutants
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This pathway describes RAS mutants with decreased intrinsic GTPase activity that therefore support increased RAS pathway activity (reviewed in Prior et al, 2012; Pylayeva and Gupta, 2011, King et al, 2013; Cox and Der, 2010).
Literature References
PubMed ID Title Journal Year
21993244 RAS oncogenes: weaving a tumorigenic web

Grabocka, E, Pylayeva-Gupta, Y, Bar-Sagi, D

Nat. Rev. Cancer 2011
23443682 Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis

Lapinski, PE, Lubeck, BA, King, PD

Sci Signal 2013
22589270 A comprehensive survey of Ras mutations in cancer

Lewis, PD, Mattos, C, Prior, IA

Cancer Res. 2012
21686117 Ras history: The saga continues

Der, CJ, Cox, AD

Small GTPases 2010
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Authored
Rothfels, K  (2015-05-18)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Rothfels, K  (2021-09-08)
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