Reactome | TPMT transfers methyl group to 6TIMP, forming 6MeTIMP

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TPMT transfers methyl group to 6TIMP, forming 6MeTIMP Show undefined attributes

authored	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
catalystActivity	[CatalystActivity:158629] thiopurine S-methyltransferase activity of TPMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
dbId	9748979
displayName	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
edited	[InstanceEdit:9748997] Jassal, Bijay, 2021-07-29
eventOf	[Pathway:R-HSA-9748787] Azathioprine ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8768] xenobiotic catabolic process
input	[SimpleEntity:R-ALL-9748992] 6TIMP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9750256] Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP 6TIMP--TPMT-->6MeTIMP
orthologousEvent	[Reaction:R-GGA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Gallus gallus [Reaction:R-XTR-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Xenopus tropicalis [Reaction:R-DRE-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Danio rerio [Reaction:R-SSC-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Sus scrofa [Reaction:R-BTA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Bos taurus [Reaction:R-CFA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Canis familiaris [Reaction:R-RNO-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Rattus norvegicus [Reaction:R-MMU-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Mus musculus
output	[SimpleEntity:R-ALL-9748944] 6MeTIMP [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP - Homo sapiens
releaseDate	2021-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9756856] Huddart, Rachel, 2021-10-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9748979
summation	[Summation:9750561] Thiopurine methyltransferase (TPMT) can methylate thiopurine...

Referrals

(precedingEvent)	[Reaction:R-HSA-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Reaction:R-HSA-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-9748787] Azathioprine ADME

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