Reactome | TPMT transfers methyl group to 6TIMP, forming 6MeTIMP

Schema > Reaction > Entries

TPMT transfers methyl group to 6TIMP, forming 6MeTIMP Show undefined attributes

catalystActivity	[CatalystActivity:10114941] thiopurine S-methyltransferase activity of TPMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214837
displayName	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
eventOf	[Pathway:R-RNO-9748787] Azathioprine ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region - Rattus norvegicus [Reaction:R-RNO-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:8768] xenobiotic catabolic process
inferredFrom	[Reaction:R-HSA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Homo sapiens
input	[SimpleEntity:R-ALL-9748992] 6TIMP [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TPMT transfers methyl group to 6TIMP, forming 6MeTIMP 6TIMP--TPMT-->6MeTIMP
output	[SimpleEntity:R-ALL-9748944] 6MeTIMP [cytosol] [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-RNO-9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9748979
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-RNO-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region [Reaction:R-RNO-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region
(inferredTo)	[Reaction:R-HSA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP

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