TPMT transfers methyl group to 6TIMP, forming 6MeTIMP

Stable Identifier
R-HSA-9748979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
6TIMP--TPMT-->6MeTIMP
ReviewStatus
5/5
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TPMT transfers methyl group to 6TIMP, forming 6MeTIMP
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Thiopurine methyltransferase (TPMT) can methylate thiopurine drugs and its metabolites (Weinshilboum et al. 1978). The methylation of 6-thioinosine 5’-monophosphate (6TIMP) leads to formation of 6-methylthioinosine monophosphate (6MeTIMP). Although an inactive metabolite in terms of inhibiting DNA and RNA synthesis, 6MeTIMP is still capable of inhibiting purine de novo synthesis (Bökkerink et al. 1993, Karim et al. 2013).
Literature References
PubMed ID Title Journal Year
657528 Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

Weinshilboum, RM, Raymond, FA, Pazmiño, PA

Clin Chim Acta 1978
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Input
Output
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as an event of
Event Information
Go Biological Process
xenobiotic catabolic process (0042178)
Catalyst Activity

thiopurine S-methyltransferase activity of TPMT [cytosol]

Physical Entity
TPMT [cytosol] (Homo sapiens)
Activity
thiopurine S-methyltransferase activity (GO:0008119)
Orthologous Events
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Bos taurus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Canis familiaris)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Danio rerio)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Gallus gallus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Mus musculus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Rattus norvegicus)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Sus scrofa)
TPMT transfers methyl group to 6TIMP, forming 6MeTIMP (Xenopus tropicalis)
Authored
Jassal, B  (2021-07-29)
Reviewed
Huddart, R  (2021-10-19)
Created
Jassal, B  (2021-07-29)
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