Reactome | SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3

Schema > Reaction > Entries

SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3 Show undefined attributes

authored	[InstanceEdit:9727867] Stephan, Ralf, 2021-04-16
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9727863] Stephan, Ralf, 2021-04-19
crossReference	[DatabaseIdentifier:12020764] Mondo:0005091
dbId	9727922
disease	[Disease:9678120] severe acute respiratory syndrome
displayName	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3
edited	[InstanceEdit:9815358] Stephan, Ralf, 2022-08-17
eventOf	[Pathway:R-HSA-9735871] SARS-CoV-1 targets host intracellular signalling and regulatory pathways - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-170855] SMAD3 [cytosol] [Complex:R-COV-9683649] SUMO1-K62-p-S177-N dimer [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9727871] Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling [LiteratureReference:9727877] Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19 [LiteratureReference:9727891] Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3
output	[Complex:R-HSA-9727945] SMAD3:SUMO1-K62-p-S177-Ncap dimer [cytosol]
precedingEvent	[Reaction:R-HSA-9683634] Dimerisation of nucleoprotein - Homo sapiens
relatedSpecies	[Species:9678119] Human SARS coronavirus
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713569] D'Eustachio, Peter, 2021-01-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9727922
summation	[Summation:9727934] Transforming growth factor-? (TGF-beta) is a well characteri...

Referrals

(hasEvent)

[Pathway:R-HSA-9735871] SARS-CoV-1 targets host intracellular signalling and regulatory pathways

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