Transforming growth factor-? (TGF-beta) is a well characteri...

created [InstanceEdit:9727863] Stephan, Ralf, 2021-04-19
dbId 9727934
displayName Transforming growth factor-? (TGF-beta) is a well characteri...
modified [InstanceEdit:9729240] Stephan, Ralf, 2021-04-25
schemaClass Summation
text Transforming growth factor-? (TGF-beta) is a well characterized cytokine and controls a variety of biological processes, it plays a pivotal role in pulmonary fibrosis. SARS-CoV-1 nucleocapsid protein (N) associates with SMAD3 and promotes SMAD3-EP300 complex formation while it interferes with the complex formation between SMAD3 and SMAD4. By this mechanism N modulates TGF-beta signaling to block apoptosis of SARS-CoV-infected host cells and meanwhile promote tissue fibrosis (Zhao et al, 2008). Elevated PAI-1 levels, pulmonary fibrosis, and key components of the TGF-beta signaling pathway are also implicated in COVID-19 (Whyte et al, 2020; Wei et al, 2020).
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