SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3

Stable Identifier
R-HSA-9727922
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
ReviewStatus
5/5
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General
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Transforming growth factor-β (TGF-beta) is a well characterized cytokine and controls a variety of biological processes, it plays a pivotal role in pulmonary fibrosis. SARS-CoV-1 nucleocapsid protein (N) associates with SMAD3 and promotes SMAD3-EP300 complex formation while it interferes with the complex formation between SMAD3 and SMAD4. By this mechanism N modulates TGF-beta signaling to block apoptosis of SARS-CoV-infected host cells and meanwhile promote tissue fibrosis (Zhao et al, 2008). Elevated PAI-1 levels, pulmonary fibrosis, and key components of the TGF-beta signaling pathway are also implicated in COVID-19 (Whyte et al, 2020; Wei et al, 2020).
Literature References
PubMed ID Title Journal Year
18055455 Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling

Chen, YG, Zhao, X, Nicholls, JM

J Biol Chem 2008
33147444 Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Kadoch, C, Mankowski, MC, Chen, H, Alfajaro, MM, van Dijk, D, Surovtseva, YV, Wei, J, DeWeirdt, PC, de Miguel, FJ, Cai, WL, Orchard, RC, Patil, A, Politi, K, Hanna, RE, Lee, B, Oguntuyo, KY, Lindenbach, BD, Graziano, VR, Chen, JS, Schmitz, CO, Yan, Q, Doench, JG, Abriola, L, Strine, MS, Ravindra, NG, Wilen, CB, Simon, MD, Gasque, V, Lu-Culligan, WJ, Zhang, SM, Filler, RB

Cell 2021
32329246 Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19

Chowdary, P, Mutch, NJ, Whyte, CS, Morrow, GB, Mitchell, JL

J Thromb Haemost 2020
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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