PGR binds PGR agonists

Stable Identifier
Reaction [binding]
Homo sapiens
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The actions of progesterone, a critical regulator of normal female reproductive function in the uterus, the ovary, the mammary gland and the brain, are mediated via the progesterone receptor (PGR). PGR agonists (Schindler et al. 2003, Kuhl 2005) are primarily used for birth control and as a part of menopausal hormone therapy and for the treatment of gynecological disorders. PGR agonists include the retroprogesterone dydrogestrone (Rižner et al. 2011), the 17alpha-hydroxyprogesterone derivative medroxyprogesterone (Zhi et al. 1998), and the 19-nortestosterone derivatives norethisterone (Edwards et al. 1998) and levonorgestrel (Bergink et al. 1983).
Literature References
PubMed ID Title Journal Year
9464361 5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents

Marschke, KB, Mais, DE, Jones, TK, Gottardis, MM, Edwards, JP, West, SJ

J. Med. Chem. 1998
9667968 Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists

Wang, MW, Jones, TK, Gottardis, MM, Edwards, JP, West, SJ, Zhi, L, Pooley, CL, Pathirana, C, Tegley, CM, Schrader, WT

J. Med. Chem. 1998
6645495 Binding of progestagens to receptor proteins in MCF-7 cells

van Meel, F, Turpijn, EW, van der Vies, J, Bergink, EW

J. Steroid Biochem. 1983
21376746 Selectivity and potency of the retroprogesterone dydrogesterone in vitro

van der Burg, B, Müller-Vieira, U, Turek-Etienne, T, Rižner, TL, Sonneveld, E, Doucette, C, Brožič, P, Husen, B, Böcker, C

Steroids 2011
9464360 5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists

Marschke, KB, Mais, DE, Jones, TK, Gottardis, MM, Zhi, L, Kallel, EA, Tegley, CM

J. Med. Chem. 1998
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