Reactome | TP53 R337C [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9726120] Orlic-Milacic, Marija, 2021-04-05
crossReference	[DatabaseIdentifier:12021428] Mondo:0018875 [DatabaseIdentifier:9726123] COSMIC:COSV52669243
dbId	9726118
disease	[Disease:1500689] cancer [Disease:9726249] Li-Fraumeni syndrome
displayName	TP53 R337C [nucleoplasm]
endCoordinate	393
hasModifiedResidue	[ReplacedResidue:9726122] L-arginine 337 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:9726113] Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus [LiteratureReference:9726245] Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome [LiteratureReference:9726286] Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members [LiteratureReference:9726293] Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain
maxDepth	1
memberOf	[CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9726294] Orlic-Milacic, Marija, 2021-04-06
name	TP53 R337C
referenceEntity	[ReferenceGeneProduct:uniprot:P04637] UniProt:P04637 TP53
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9726118
startCoordinate	1

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