Reactome | Defective TP53 does not tetramerize

Schema > FailedReaction > Entries

Defective TP53 does not tetramerize Show undefined attributes

authored	[InstanceEdit:9726526] Orlic-Milacic, Marija, 2021-04-07
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9723904] Orlic-Milacic, Marija, 2021-03-18
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9723906
disease	[Disease:1500689] cancer
displayName	Defective TP53 does not tetramerize
edited	[InstanceEdit:9729597] Orlic-Milacic, Marija, 2021-05-03
entityFunctionalStatus	[EntityFunctionalStatus:9726239] loss_of_function and partial_loss_of_function of TP53 mutants (tetramerization) [nucleoplasm]
eventOf	[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability - Homo sapiens
input	4 × [CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9726064] Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function [LiteratureReference:9726103] p53 mutants without a functional tetramerisation domain are not oncogenic [LiteratureReference:9726113] Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus [LiteratureReference:9726245] Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome [LiteratureReference:9726252] Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells [LiteratureReference:9726286] Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members [LiteratureReference:9726293] Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain [LiteratureReference:9726301] A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer [LiteratureReference:9726305] Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand [LiteratureReference:9726313] Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation [LiteratureReference:6804858] p53 oligomerization and DNA looping are linked with transcriptional activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective TP53 does not tetramerize
normalReaction	[Reaction:R-HSA-6804762] TP53 forms homotetramers
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729599] Sakaguchi, Kazuyasu, 2021-04-30
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9723906
summation	[Summation:9726370] A number of nonsense and frameshift truncations result in mu...

Referrals

(hasEvent)

[Pathway:R-HSA-9723905] Loss of function of TP53 in cancer due to loss of tetramerization ability

Cite Us!