Reactome | GNRHR binds GNRHR peptide antagonists

Schema > Reaction > Entries

GNRHR binds GNRHR peptide antagonists Show undefined attributes

authored	[InstanceEdit:9718363] Jassal, Bijay, 2021-03-17
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9718363] Jassal, Bijay, 2021-03-17
dbId	9718394
definition	Antagonist
displayName	GNRHR binds GNRHR peptide antagonists
edited	[InstanceEdit:9718363] Jassal, Bijay, 2021-03-17 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
eventOf	[Pathway:R-HSA-375281] Hormone ligand-binding receptors - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-391370] GNRHR [plasma membrane] [DefinedSet:R-ALL-9718382] GNRHR peptide antagonists [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9718380] Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay [LiteratureReference:9718378] Selection and characterization of mammalian cell lines with stable over-expression of human pituitary receptors for gonadoliberin [LiteratureReference:9724511] In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GNRHR binds GNRHR peptide antagonists
orthologousEvent	[Reaction:R-CEL-9718394] GNRHR binds GNRHR peptide antagonists - Caenorhabditis elegans [Reaction:R-DME-9718394] GNRHR binds GNRHR peptide antagonists - Drosophila melanogaster [Reaction:R-XTR-9718394] GNRHR binds GNRHR peptide antagonists - Xenopus tropicalis [Reaction:R-DRE-9718394] GNRHR binds GNRHR peptide antagonists - Danio rerio [Reaction:R-SSC-9718394] GNRHR binds GNRHR peptide antagonists - Sus scrofa [Reaction:R-BTA-9718394] GNRHR binds GNRHR peptide antagonists - Bos taurus [Reaction:R-CFA-9718394] GNRHR binds GNRHR peptide antagonists - Canis familiaris [Reaction:R-RNO-9718394] GNRHR binds GNRHR peptide antagonists - Rattus norvegicus [Reaction:R-MMU-9718394] GNRHR binds GNRHR peptide antagonists - Mus musculus
output	[Complex:R-HSA-9718342] GNRHR:GNRHR peptide antagonists [plasma membrane]
releaseDate	2022-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9718394
summation	[Summation:9724535] Gonadotropin-releasing hormone (GNRH) is a naturally occurri...

Referrals

(hasEvent)

[Pathway:R-HSA-375281] Hormone ligand-binding receptors