Gonadotropin-releasing hormone (GNRH) is a naturally occurri...

created [InstanceEdit:9724537] Jassal, Bijay, 2021-03-24
dbId 9724535
displayName Gonadotropin-releasing hormone (GNRH) is a naturally occurri...
literatureReference
schemaClass Summation
text Gonadotropin-releasing hormone (GNRH) is a naturally occurring decapeptide that modulates the hypothalamic-pituitary-gonadal axis. GNHR binding to GNRH receptors causes the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which, in turn, affect the downstream synthesis and release of the sex hormones testosterone, dihydrotestosterone, estrone, and estradiol.

GNRHR peptide antagonists antagonize the GNRHR and thus the action of GNRH (Beckers et al. 1995, Beckers et al. 1997). In men, the reduction in LH leads to rapid suppression of testosterone production in the testes; in women it leads to suppression of estradiol and progesterone production from the ovaries. GNRHR peptide antagonists are used in the treatment of prostate cancer (abarelix, degaralix) (Debruyne 2004, Van Poppel 2010, Sakai et al. 2015) or female infertility in assisted reproduction (cetrorelix, ganirelix) (Diedrich et al. 2001, Al-Inany et al. 2016).
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