GNRHR binds GNRHR peptide antagonists

Stable Identifier
R-HSA-9718394
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GNRHR binds GNRHR peptide antagonists
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gonadotropin-releasing hormone (GNRH) is a naturally occurring decapeptide that modulates the hypothalamic-pituitary-gonadal axis. GNHR binding to GNRH receptors causes the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which, in turn, affect the downstream synthesis and release of the sex hormones testosterone, dihydrotestosterone, estrone, and estradiol.

GNRHR peptide antagonists antagonize the GNRHR and thus the action of GNRH (Beckers et al. 1995, Beckers et al. 1997). In men, the reduction in LH leads to rapid suppression of testosterone production in the testes; in women it leads to suppression of estradiol and progesterone production from the ovaries. GNRHR peptide antagonists are used in the treatment of prostate cancer (abarelix, degaralix) (Debruyne 2004, Van Poppel 2010, Sakai et al. 2015) or female infertility in assisted reproduction (cetrorelix, ganirelix) (Diedrich et al. 2001, Al-Inany et al. 2016).
Literature References
PubMed ID Title Journal Year
7649152 Selection and characterization of mammalian cell lines with stable over-expression of human pituitary receptors for gonadoliberin

Marheineke, K, Reiländer, H, Hilgard, P, Beckers, T

Eur. J. Biochem. 1995
25811175 In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth

Martinez-Arguelles, DB, Sakai, M, Patterson, NH, Chaurand, P, Papadopoulos, V

PLoS One 2015
9300077 Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay

Reiländer, H, Hilgard, P, Beckers, T

Anal. Biochem. 1997
Participants
Input
Output
Participates
as an event of
Orthologous Events
GNRHR binds GNRHR peptide antagonists (Bos taurus)
GNRHR binds GNRHR peptide antagonists (Caenorhabditis elegans)
GNRHR binds GNRHR peptide antagonists (Canis familiaris)
GNRHR binds GNRHR peptide antagonists (Danio rerio)
GNRHR binds GNRHR peptide antagonists (Drosophila melanogaster)
GNRHR binds GNRHR peptide antagonists (Gallus gallus)
GNRHR binds GNRHR peptide antagonists (Mus musculus)
GNRHR binds GNRHR peptide antagonists (Rattus norvegicus)
GNRHR binds GNRHR peptide antagonists (Sus scrofa)
GNRHR binds GNRHR peptide antagonists (Xenopus tropicalis)
Authored
Jassal, B  (2021-03-17)
Reviewed
Huddart, R  (2022-03-01)
Created
Jassal, B  (2021-03-17)
Cite Us!