Reactome | BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9713505] BCL11A(1-219)InsDHPPA-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-9713505] BCL11A(1-219)InsDHPPA-p-7Y ALK(1058-1620) fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:9713446] Rothfels, Karen, 2021-01-26
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	9713447
disease	[Disease:1247848] non-small cell lung carcinoma
displayName	BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
endCoordinate	219
hasModifiedResidue	[FragmentInsertionModification:9713424] Insertion of residues 1058 to 1620 at 220 from UniProt:Q9UM73 ALK [FragmentReplacedModification:9713433] Replacement of residues 219 to 219 by ADHPPA [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
inDisease	true
literatureReference	[LiteratureReference:9713357] Identification of a novel crizotinib-sensitive BCL11A-ALK gene fusion in a nonsmall cell lung cancer patient
maxDepth	1
modified	[InstanceEdit:9832400] Orlic-Milacic, Marija, 2023-03-30
name	BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion fullName evidence="17"B-cell lymphoma/leukemia 11A BC11A_HUMAN
referenceEntity	[ReferenceGeneProduct:uniprot:Q9H165] UniProt:Q9H165 BCL11A
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9713447
startCoordinate	1
updateTrackers	[UpdateTracker:9905529] Update Tracker - [EntityWithAccessionedSequence:9713447] BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] - v85:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9905529] Update Tracker - [EntityWithAccessionedSequence:9713447] BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] - v85:[modifyName]
(hasComponent)	[Complex:R-HSA-9713505] BCL11A(1-219)InsDHPPA-p-7Y ALK(1058-1620) fusion dimer [cytosol]

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