ALK fusions phosphorylate PLCG1

Stable Identifier
R-HSA-9712086
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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PLC gamma is phosphorylated downstream of ALK fusions, activating it. PLC gamma signaling promotes cellular proliferation and differentiation (Bai et al, 1998; reviewed in Chiarle et al, 2008; Palmer et al, 2009).

Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Dieter, P, Morris, SW, Bai, RY, Duyster, J, Peschel, C

Mol. Cell. Biol. 1998
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]

Normal reaction
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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