ALK fusions phosphorylate PLCG1

Stable Identifier
R-HSA-9712086
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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ALK fusions phosphorylate PLCG1
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PLC gamma is phosphorylated downstream of ALK fusions, activating it. PLC gamma signaling promotes cellular proliferation and differentiation (Bai et al, 1998; reviewed in Chiarle et al, 2008; Palmer et al, 2009).
Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
9819383 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

Dieter, P, Morris, SW, Bai, RY, Duyster, J, Peschel, C

Mol. Cell. Biol. 1998
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane]

Physical Entity
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Normal reaction
Active ALK phosphorylates PLCG1 (Homo sapiens)
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2021-03-22)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2021-01-14)
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