Reactome | GSDME variant does not bind PIPs

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GSDME variant does not bind PIPs Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
crossReference	[DatabaseIdentifier:12020961] Mondo:0004989
dbId	9710468
disease	[Disease:1500689] cancer [Disease:9701259] breast carcinoma [Disease:9662153] colon adenocarcinoma [Disease:6802264] gastric adenocarcinoma [Disease:1248679] head and neck squamous cell carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1614289] melanoma
displayName	GSDME variant does not bind PIPs
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
entityFunctionalStatus	[EntityFunctionalStatus:9710443] loss_of_function of GSDME variant [cytosol]
eventOf	[Pathway:R-HSA-9710421] Defective pyroptosis - Homo sapiens
input	[CandidateSet:R-HSA-9710467] GSDME variant [cytosol] [DefinedSet:R-ALL-5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSDME variant does not bind PIPs
normalReaction	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715446] Zhang, Zhibin, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9710468
summation	[Summation:9710406] Cancer?related loss of function (LOF) mutations in the N?ter...
updateTrackers	[UpdateTracker:9776118] Update Tracker - [FailedReaction:9710468] GSDME variant does not bind PIPs - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776118] Update Tracker - [FailedReaction:9710468] GSDME variant does not bind PIPs - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-9710421] Defective pyroptosis

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