Reactome | Defective pyroptosis

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Defective pyroptosis Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
crossReference	[DatabaseIdentifier:12020961] Mondo:0004989
dbId	9710421
disease	[Disease:1500689] cancer [Disease:9701259] breast carcinoma [Disease:9662153] colon adenocarcinoma [Disease:6802264] gastric adenocarcinoma [Disease:1248679] head and neck squamous cell carcinoma [Disease:8853117] lung adenocarcinoma [Disease:1614289] melanoma
displayName	Defective pyroptosis
doi	10.3180/R-HSA-9710421.2
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-9645723] Diseases of programmed cell death - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9710490] The GSDME gene promoter is hypermethylated - Homo sapiens [Reaction:R-HSA-9710480] Decitabine triphosphate incorporates into DNA - Homo sapiens [FailedReaction:R-HSA-9710468] GSDME variant does not bind PIPs - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-06-14
literatureReference	[LiteratureReference:9710262] Emerging insights on the role of gasdermins in infection and inflammatory diseases [LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity [LiteratureReference:9710162] Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Defective pyroptosis
normalPathway	[Pathway:R-HSA-5620971] Pyroptosis
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715446] Zhang, Zhibin, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9710421
summation	[Summation:9710422] Pyroptosis is a form of lytic inflammatory programmed cell d...
updateTrackers	[UpdateTracker:9776091] Update Tracker - [Pathway:9710421] Defective pyroptosis - v77:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776091] Update Tracker - [Pathway:9710421] Defective pyroptosis - v77:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9645723] Diseases of programmed cell death