Reactome | Decitabine triphosphate incorporates into DNA

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Decitabine triphosphate incorporates into DNA Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:68508] DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9710398] Shamovsky, Veronica, 2020-12-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9710480
disease	[Disease:1500689] cancer
displayName	Decitabine triphosphate incorporates into DNA
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-9710421] Defective pyroptosis - Homo sapiens
input	[SimpleEntity:R-ALL-29604] dATP [nucleoplasm] [SimpleEntity:R-ALL-30185] dCTP [nucleoplasm] [ChemicalDrug:R-ALL-9710463] Decitabine triphosphate [nucleoplasm] [SimpleEntity:R-ALL-29892] dGTP [nucleoplasm] [SimpleEntity:R-ALL-30187] dTTP [nucleoplasm] [Complex:R-HSA-68423] RNA primer:origin duplex:DNA polymerase alpha:primase complex [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[Book:9710444] 9780128022085 Egger, Gerda DNA Methyltransferase Inhibitors Drug Discovery in Cancer Epigenetics
maxDepth	1
modified	[InstanceEdit:9964232] Shamovsky, Veronica, 2025-08-20
name	Decitabine triphosphate incorporates into DNA
output	[Complex:R-HSA-9710454] RNA primer:decitabine-DNA primer:origin duplex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-68913] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715446] Zhang, Zhibin, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9710480
summation	[Summation:9710472] Cellular uptake of decitabine or 5?aza?2??deoxycytidine is m...

Referrals

(hasEvent)

[Pathway:R-HSA-9710421] Defective pyroptosis

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