Reactome | GSDME expression mediated by TP53, TP63

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GSDME expression mediated by TP53, TP63 Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9710316] Shamovsky, Veronica, 2020-12-28
dbId	9710306
displayName	GSDME expression mediated by TP53, TP63
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-5620971] Pyroptosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9710263] GZMB cleaves GSDME - Homo sapiens [BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9710319] GSDME gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9710326] The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage [LiteratureReference:9710328] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GSDME expression mediated by TP53, TP63
output	[EntityWithAccessionedSequence:R-HSA-9647620] GSDME [cytosol]
precedingEvent	[Reaction:R-HSA-9710323] TP53 or TP63 binds the GSDME gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9710307] Positive gene expression regulation by '(p-S15,S20-TP53,TP63):GSDME gene [nucleoplasm]'
regulationReference	[RegulationReference:9710325] Positive gene expression regulation by '(p-S15,S20-TP53,TP63):GSDME gene [nucleoplasm]' The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9710306
summation	[Summation:9710305] Gasdermin E (GSDME, also known as DFNA5) was identified as a...

Referrals

(hasEvent)	[Pathway:R-HSA-5620971] Pyroptosis
(precedingEvent)	[BlackBoxEvent:R-HSA-9710263] GZMB cleaves GSDME [BlackBoxEvent:R-HSA-9647632] CASP3 cleaves GSDME

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