Gasdermin E (GSDME, also known as DFNA5) was identified as a direct target gene of the transcription factor p53 (Masuda Y et al. 2006). Increased expression of GSDME in a human hepatocellular carcinoma cell line (HepG2) treated with H2O2, UV (30 J/m2) or gamma rays (50 Gy) was p53‑dependent. TP53 (p53) induced GSDME expression via a specific p53 binding site in intron 1 of the GSDME gene (Masuda Y et al. 2006). In addition, P63γ and p73β also upregulated GSDME in demethylating agent 5‑aza‑2'‑deoxycytidine (DAC)‑treated human breast cancer MCF7 cells, suggesting that the GSDME expression can be regulated by multiple members of the p53 family (Fujikane T et al. 2010).
Masuda, Y, Futamura, M, Kamino, H, Nakamura, Y, Kitamura, N, Ohnishi, S, Miyamoto, Y, Ichikawa, H, Ohta, T, Ohki, M, Kiyono, T, Egami, H, Baba, H, Arakawa, H
Fujikane, T, Nishikawa, N, Toyota, M, Suzuki, H, Nojima, M, Maruyama, R, Ashida, M, Ohe-Toyota, M, Kai, M, Nishidate, T, Sasaki, Y, Ohmura, T, Hirata, K, Tokino, T
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