GSDME expression mediated by TP53, TP63

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Gasdermin E (GSDME, also known as DFNA5) was identified as a direct target gene of the transcription factor p53 (Masuda Y et al. 2006). Increased expression of GSDME in a human hepatocellular carcinoma cell line (HepG2) treated with H2O2, UV (30 J/m2) or gamma rays (50 Gy) was p53‑dependent. TP53 (p53) induced GSDME expression via a specific p53 binding site in intron 1 of the GSDME gene (Masuda Y et al. 2006). In addition, P63γ and p73β also upregulated GSDME in demethylating agent 5‑aza‑2'‑deoxycytidine (DAC)‑treated human breast cancer MCF7 cells, suggesting that the GSDME expression can be regulated by multiple members of the p53 family (Fujikane T et al. 2010).

Literature References
PubMed ID Title Journal Year
19859801 Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer

Ohe-Toyota, M, Ohmura, T, Toyota, M, Nishikawa, N, Kai, M, Sasaki, Y, Fujikane, T, Tokino, T, Hirata, K, Ashida, M, Suzuki, H, Maruyama, R, Nojima, M, Nishidate, T

Breast Cancer Res Treat 2010
16897187 The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage

Arakawa, H, Ohnishi, S, Ichikawa, H, Futamura, M, Ohta, T, Baba, H, Ohki, M, Miyamoto, Y, Nakamura, Y, Egami, H, Kamino, H, Kitamura, N, Kiyono, T, Masuda, Y

J Hum Genet 2006
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