Reactome | GZMB cleaves GSDME

Schema > BlackBoxEvent > Entries

GZMB cleaves GSDME Show undefined attributes

authored	[InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09
catalystActivity	[CatalystActivity:140427] serine-type endopeptidase activity of GZMB [cytosol]
catalystActivityReference	[CatalystActivityReference:9710253] serine-type endopeptidase activity of GZMB [cytosol] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9710266] Shamovsky, Veronica, 2020-12-25
dbId	9710263
displayName	GZMB cleaves GSDME
edited	[InstanceEdit:9715950] Shorser, Solomon, 2021-02-17
eventOf	[Pathway:R-HSA-5620971] Pyroptosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs - Homo sapiens [Reaction:R-HSA-9710354] GSDME (1-270) binds cardiolipin - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9647620] GSDME [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9710028] Gasdermin E suppresses tumour growth by activating anti-tumour immunity
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	GZMB cleaves GSDME
orthologousEvent	[BlackBoxEvent:R-BTA-9710263] GZMB cleaves GSDME - Bos taurus [BlackBoxEvent:R-XTR-9710263] GZMB cleaves GSDME - Xenopus tropicalis [BlackBoxEvent:R-DRE-9710263] GZMB cleaves GSDME - Danio rerio [BlackBoxEvent:R-SSC-9710263] GZMB cleaves GSDME - Sus scrofa [BlackBoxEvent:R-CFA-9710263] GZMB cleaves GSDME - Canis familiaris [BlackBoxEvent:R-RNO-9710263] GZMB cleaves GSDME - Rattus norvegicus [BlackBoxEvent:R-MMU-9710263] GZMB cleaves GSDME - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9647615] GSDME (271-496) [cytosol] [EntityWithAccessionedSequence:R-HSA-9647689] GSDME(1-270) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9710306] GSDME expression mediated by TP53, TP63 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9715448] Kanneganti, Thirumala-Devi, 2021-02-17 [InstanceEdit:9715449] D'Eustachio, Peter, 2021-02-17 [InstanceEdit:9728818] Shao, Feng, 2021-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9710263
summation	[Summation:9710265] Granzyme B (GZMB) belongs to a family of serine proteases st...
updateTrackers	[UpdateTracker:9776125] Update Tracker - [BlackBoxEvent:9710263] GZMB cleaves GSDME - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776125] Update Tracker - [BlackBoxEvent:9710263] GZMB cleaves GSDME - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-5620971] Pyroptosis
(precedingEvent)	[Reaction:R-HSA-9647660] GSDME (1-270) binds PIPs [Reaction:R-HSA-9710354] GSDME (1-270) binds cardiolipin