Reactome | GZMB cleaves GSDME

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GZMB cleaves GSDME Show undefined attributes

catalystActivity	[CatalystActivity:10658565] serine-type endopeptidase activity of GZMB [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10723139
displayName	GZMB cleaves GSDME
eventOf	[Pathway:R-XTR-5620971] Pyroptosis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9647660] GSDME (1-270) binds PIPs - Xenopus tropicalis [Reaction:R-XTR-9710354] GSDME (1-270) binds cardiolipin - Xenopus tropicalis
inferredFrom	[BlackBoxEvent:R-HSA-9710263] GZMB cleaves GSDME - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-9647620] gsdme [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GZMB cleaves GSDME
output	[EntityWithAccessionedSequence:R-XTR-9647615] gsdme [cytosol] [EntityWithAccessionedSequence:R-XTR-9647689] gsdme [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9710263
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5620971] Pyroptosis
(precedingEvent)	[Reaction:R-XTR-9647660] GSDME (1-270) binds PIPs [Reaction:R-XTR-9710354] GSDME (1-270) binds cardiolipin
(inferredTo)	[BlackBoxEvent:R-HSA-9710263] GZMB cleaves GSDME