Reactome | BRCA2 translocates to the nucleus

Schema > BlackBoxEvent > Entries

BRCA2 translocates to the nucleus Show undefined attributes

authored	[InstanceEdit:9709291] Orlic-Milacic, Marija, 2020-12-11
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9709263] Orlic-Milacic, Marija, 2020-12-11
dbId	9709273
diseaseReaction	[FailedReaction:R-HSA-9709268] Defective BRCA2 does not translocate to the nucleus - Homo sapiens
displayName	BRCA2 translocates to the nucleus
edited	[InstanceEdit:9763742] Orlic-Milacic, Marija, 2022-02-04
eventOf	[Pathway:R-HSA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Homo sapiens
followingEvent	[Reaction:R-HSA-5685242] CHEK1 phosphorylates BRCA2 - Homo sapiens
input	[Complex:R-HSA-9763138] BRCA2:SEM1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9709272] Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations [LiteratureReference:9709271] Nuclear localization signals of the BRCA2 protein [LiteratureReference:9763147] Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance [LiteratureReference:9763174] A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRCA2 translocates to the nucleus
output	[Complex:R-HSA-9763135] BRCA2:SEM1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9763137] BRCA2 binds SEM1 (DSS1) - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9763679] Liu, Jie, 2022-01-26 [InstanceEdit:9763678] Le, Hang Phuong, 2022-01-26 [InstanceEdit:9763681] Heyer, Wolf-Dietrich, 2022-01-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9709273
summation	[Summation:9709269] BRCA2 possesses two functional nuclear localization signals ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9709268] Defective BRCA2 does not translocate to the nucleus
(hasEvent)	[Pathway:R-HSA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange
(precedingEvent)	[Reaction:R-HSA-5685242] CHEK1 phosphorylates BRCA2

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