Reactome | Presynaptic phase of homologous DNA pairing and strand exchange

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Presynaptic phase of homologous DNA pairing and strand exchange Show undefined attributes

authored	[InstanceEdit:73965] Thompson, L, 2003-07-14 15:03:24 [InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693616
deleted	[Deleted:6793537] Deletion of instance: 76003
displayName	Presynaptic phase of homologous DNA pairing and strand exchange
doi	10.3180/R-HSA-5693616.3
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693579] Homologous DNA Pairing and Strand Exchange - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5685230] CHEK1 phosphorylates RAD51 - Homo sapiens [Reaction:R-HSA-9763137] BRCA2 binds SEM1 (DSS1) - Homo sapiens [BlackBoxEvent:R-HSA-9709273] BRCA2 translocates to the nucleus - Homo sapiens [Reaction:R-HSA-5685242] CHEK1 phosphorylates BRCA2 - Homo sapiens [Reaction:R-HSA-5693561] RAD51 binds BRCA2 at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-5685318] BCDX2 complex formation - Homo sapiens [Reaction:R-HSA-5685341] BCDX2 complex stabilizes RAD51 filament - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[Book:111373] 9780306479878 Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks in Mammalian Cells Eukaryotic DNA Damage Surveillance and Repair Caldecott, Keith W [LiteratureReference:5685232] The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair [LiteratureReference:5685247] The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage [LiteratureReference:5685330] Purified human BRCA2 stimulates RAD51-mediated recombination [LiteratureReference:5685333] Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA [LiteratureReference:5685323] The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA [LiteratureReference:5685616] The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction [LiteratureReference:5685312] Identification and purification of two distinct complexes containing the five RAD51 paralogs [LiteratureReference:5685308] Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway [LiteratureReference:5685621] The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Presynaptic phase of homologous DNA pairing and strand exchange
orthologousEvent	[Pathway:R-DDI-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Dictyostelium discoideum [Pathway:R-PFA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Plasmodium falciparum [Pathway:R-SCE-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Saccharomyces cerevisiae [Pathway:R-SPO-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Schizosaccharomyces pombe [Pathway:R-CEL-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Caenorhabditis elegans [Pathway:R-DME-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Drosophila melanogaster [Pathway:R-GGA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Gallus gallus [Pathway:R-DRE-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Danio rerio [Pathway:R-SSC-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Sus scrofa [Pathway:R-BTA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Bos taurus [Pathway:R-CFA-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Canis familiaris [Pathway:R-RNO-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Rattus norvegicus [Pathway:R-MMU-5693616] Presynaptic phase of homologous DNA pairing and strand exchange - Mus musculus
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5693616
summation	[Summation:5693613] The presynaptic phase of homologous DNA pairing and strand e...
updateTrackers	[UpdateTracker:9776025] Update Tracker - [Pathway:5693616] Presynaptic phase of homologous DNA pairing and strand exchange - v78:[updateContainedRLE] [UpdateTracker:9775238] Update Tracker - [Pathway:5693616] Presynaptic phase of homologous DNA pairing and strand exchange - v80:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9776025] Update Tracker - [Pathway:5693616] Presynaptic phase of homologous DNA pairing and strand exchange - v78:[updateContainedRLE] [UpdateTracker:9775238] Update Tracker - [Pathway:5693616] Presynaptic phase of homologous DNA pairing and strand exchange - v80:[addHasEvent, updateContainedRLE]
(replacementInstances)	[Deleted:6793537] Deletion of instance: 76003
(hasEvent)	[Pathway:R-HSA-5693579] Homologous DNA Pairing and Strand Exchange

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