CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

Stable Identifier
R-HSA-9707977
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Polyubiquitinated CSF3R, believed to be in a complex with with CSF3 and other signaling molecules, transits from endosomes to lysosomes (Aarts et al. 2004, Irandoust et al. 2007, Wölfler et al. 2009).

Literature References
PubMed ID Title Journal Year
19453968 Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor

Wölfler, A, Irandoust, M, Meenhuis, A, Gits, J, Roovers, O, Touw, IP

Traffic 2009
14512302 Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics

Aarts, LH, Roovers, O, Ward, AC, Touw, IP

Blood 2004
17363902 Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Irandoust, MI, Aarts, LH, Roovers, O, Gits, J, Erkeland, SJ, Touw, IP

EMBO J 2007
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