Reactome | FLT3 signaling by CBL mutants

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FLT3 signaling by CBL mutants Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
created	[InstanceEdit:9706378] Rothfels, Karen, 2020-11-04
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12020745] Mondo:0004992 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	9706377
disease	[Disease:1500689] cancer
displayName	FLT3 signaling by CBL mutants
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9682385] FLT3 signaling in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9706356] CBL mutants don't ubiquitinate FLT3 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML [LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes [LiteratureReference:9706088] Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias [LiteratureReference:9706115] Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	FLT3 signaling by CBL mutants
normalPathway	[Pathway:R-HSA-9607240] FLT3 Signaling
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9706377
summation	[Summation:9706376] Missense and splicing mutants have been identified in the E3...

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[Pathway:R-HSA-9682385] FLT3 signaling in disease

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