Missense and splicing mutants have been identified in the E3...

created [InstanceEdit:9706378] Rothfels, Karen, 2020-11-04
dbId 9706376
displayName Missense and splicing mutants have been identified in the E3...
schemaClass Summation
text Missense and splicing mutants have been identified in the E3 ubiquitin ligase CBL in a number of cancers including acute and chronic myeloid leukemias, among others. These cancers show elevated signaling through FLT3 as a result of impaired CBL-mediated downregulation of the receptor (Sargin et al, 2007; Reindl et al, 2009; Caligiuri et al, 2007; Abbas et al, 2008).
Cite Us!