FLT3 signaling by CBL mutants

Stable Identifier
Homo sapiens
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Missense and splicing mutants have been identified in the E3 ubiquitin ligase CBL in a number of cancers including acute and chronic myeloid leukemias, among others. These cancers show elevated signaling through FLT3 as a result of impaired CBL-mediated downregulation of the receptor (Sargin et al, 2007; Reindl et al, 2009; Caligiuri et al, 2007; Abbas et al, 2008).
Literature References
PubMed ID Title Journal Year
18698078 Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

Rotmans, G, Abbas, S, Valk, PJ, Löwenberg, B

Haematologica 2008
19276253 CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes

Buske, C, Duyster, J, Reindl, C, Spiekermann, K, Vempati, S, Bohlander, SK, Humphries, KR, Greif, PA, Mellert, G, Argiropoulos, B, Hiddemann, W, Quentmeier, H, Benthaus, T, Petropoulos, K

Clin Cancer Res 2009
17475912 Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

Caligiuri, MA, Perrotti, D, Wei, M, Arnoczky, KJ, Wen, J, Whitman, SP, Bloomfield, CD, Wang, L, Marburger, TB, Yu, J, Briesewitz, R

Blood 2007
17446348 Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Berdel, WE, Grundler, R, Serve, H, Duyster, J, Brandts, C, Tickenbrock, L, Choudhary, C, Koschmieder, S, Dikic, I, Müller-Tidow, C, Schwäble, J, August, B, Thiessen, C, Crosetto, N, Sargin, B, Rensinghoff, M, Bandi, SR, Schmidt, MHH

Blood 2007
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
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