FLT3 signaling by CBL mutants

Stable Identifier
R-HSA-9706377
Type
Pathway
Species
Homo sapiens
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Missense and splicing mutants have been identified in the E3 ubiquitin ligase CBL in a number of cancers including acute and chronic myeloid leukemias, among others. These cancers show elevated signaling through FLT3 as a result of impaired CBL-mediated downregulation of the receptor (Sargin et al, 2007; Reindl et al, 2009; Caligiuri et al, 2007; Abbas et al, 2008).

Literature References
PubMed ID Title Journal Year
19276253 CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes

Reindl, C, Quentmeier, H, Petropoulos, K, Greif, PA, Benthaus, T, Argiropoulos, B, Mellert, G, Vempati, S, Duyster, J, Buske, C, Bohlander, SK, Humphries, KR, Hiddemann, W, Spiekermann, K

Clin Cancer Res 2009
18698078 Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

Abbas, S, Rotmans, G, Löwenberg, B, Valk, PJ

Haematologica 2008
17475912 Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

Caligiuri, MA, Briesewitz, R, Yu, J, Wang, L, Wei, M, Arnoczky, KJ, Marburger, TB, Wen, J, Perrotti, D, Bloomfield, CD, Whitman, SP

Blood 2007
17446348 Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Sargin, B, Choudhary, C, Crosetto, N, Schmidt, MHH, Grundler, R, Rensinghoff, M, Thiessen, C, Tickenbrock, L, Schwäble, J, Brandts, C, August, B, Koschmieder, S, Bandi, SR, Duyster, J, Berdel, WE, Müller-Tidow, C, Dikic, I, Serve, H

Blood 2007
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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BioModels Database
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