Reactome | FLT3 phosphorylates CBL

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FLT3 phosphorylates CBL Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9706349] protein tyrosine kinase activity of active FLT3:CBL [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9706352] Rothfels, Karen, 2020-11-04
dbId	9706350
displayName	FLT3 phosphorylates CBL
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9706369] Negative regulation of FLT3 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9706354] Ubiquitination of FLT3 - Homo sapiens
input	[Complex:R-HSA-9706252] active FLT3:CBL [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML [LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes [LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	FLT3 phosphorylates CBL
orthologousEvent	[Reaction:R-SSC-9706350] FLT3 phosphorylates CBL - Sus scrofa [Reaction:R-BTA-9706350] FLT3 phosphorylates CBL - Bos taurus [Reaction:R-CFA-9706350] FLT3 phosphorylates CBL - Canis familiaris [Reaction:R-MMU-9706350] FLT3 phosphorylates CBL - Mus musculus
output	[Complex:R-HSA-9706224] active FLT3:pY-CBL [plasma membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-9706293] Active FLT3 binds to CBL - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9706350
summation	[Summation:9706351] FLT3 activation leads to tyrosine phosphorylation of CBL (Sa...

Referrals

(hasEvent)	[Pathway:R-HSA-9706369] Negative regulation of FLT3
(precedingEvent)	[BlackBoxEvent:R-HSA-9706354] Ubiquitination of FLT3