FLT3 phosphorylates CBL

Stable Identifier
R-HSA-9706350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FLT3 activation leads to tyrosine phosphorylation of CBL (Sargin et al, 2007; Reindl et al, 2009). Phosphorylation of CBL is abolished in FLT3 Y589 and Y599 mutants (Heiss et al, 2006).

Literature References
PubMed ID Title Journal Year
19276253 CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes

Reindl, C, Quentmeier, H, Petropoulos, K, Greif, PA, Benthaus, T, Argiropoulos, B, Mellert, G, Vempati, S, Duyster, J, Buske, C, Bohlander, SK, Humphries, KR, Hiddemann, W, Spiekermann, K

Clin Cancer Res 2009
16684964 Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2

Heiss, E, Masson, K, Sundberg, C, Pedersen, M, Sun, J, Bengtsson, S, Rönnstrand, L

Blood 2006
17446348 Flt3-dependent transformation by inactivating c-Cbl mutations in AML

Sargin, B, Choudhary, C, Crosetto, N, Schmidt, MHH, Grundler, R, Rensinghoff, M, Thiessen, C, Tickenbrock, L, Schwäble, J, Brandts, C, August, B, Koschmieder, S, Bandi, SR, Duyster, J, Berdel, WE, Müller-Tidow, C, Dikic, I, Serve, H

Blood 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of active FLT3:CBL [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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