The 110 kDa catalytic subunit of PI3K is likely recruited to...

created [InstanceEdit:9703419] Rothfels, Karen, 2020-10-06
dbId 9703416
displayName The 110 kDa catalytic subunit of PI3K is likely recruited to...
schemaClass Summation
text The 110 kDa catalytic subunit of PI3K is likely recruited to FLT3 fusions through interaction with the p85 regulatory subunit, as is the case for the wild-type receptor. GAB2-mediated conformational changes in the p85 regulatory subunit stimulate interaction with p110, and promote PI3K/AKT signaling downstream of activated FLT3 (Zhang et al, 1999; Zhang et al, 2000; Vu et al, 2007; Masson et al, 2009; Grand et al, 2007; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019).
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