Reactome | TTT-3002-sensitive FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9702993] Rothfels, Karen, 2020-10-03
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9702992
disease	[Disease:1500689] cancer
displayName	TTT-3002-sensitive FLT3 mutants [plasma membrane]
hasMember	[Complex:R-HSA-9682330] FLT3 D835A dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682338] FLT3 D835G dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682344] FLT3 D835N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9682356] FLT3 D835Y dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9691983] FLT3 Y591_V592insVDFREYEYDH dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9695762] FLT3 F691L dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors [LiteratureReference:9702959] FLT3 kinase inhibitor TTT-3002 overcomes both activating and drug resistance mutations in FLT3 in acute myeloid leukemia [LiteratureReference:9702964] TTT-3002 is a novel FLT3 tyrosine kinase inhibitor with activity against FLT3-associated leukemias in vitro and in vivo
maxDepth	3
memberOf	[DefinedSet:R-HSA-9702522] type I TKI sensitive FLT3 mutants [plasma membrane] - Homo sapiens
name	TTT-3002-sensitive FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9702992

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