Reactome | pexidartinib-resistant FLT3 mutants

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authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
created	[InstanceEdit:9702606] Rothfels, Karen, 2020-10-01
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9702605
disease	[Disease:1500689] cancer
displayName	pexidartinib-resistant FLT3 mutants
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9702506] Drug resistance of FLT3 mutants - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-9702607] pexidartinib-resistant FLT3 mutants don't bind pexidartinib - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9703039] Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397 [LiteratureReference:9699279] FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pexidartinib-resistant FLT3 mutants
normalPathway	[Pathway:R-HSA-9607240] FLT3 Signaling
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9702605
summation	[Summation:9703059] Pexidartinib is a type II tyrosine kinase inhibitor that is ...

(hasEvent)

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