Pexidartinib is a type II tyrosine kinase inhibitor that is ...

created [InstanceEdit:9703058] Rothfels, Karen, 2020-10-05
dbId 9703059
displayName Pexidartinib is a type II tyrosine kinase inhibitor that is ...
modified [InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
schemaClass Summation
text Pexidartinib is a type II tyrosine kinase inhibitor that is active against FLT3, including the quizartinib-resistant gatekeeper mutation F691L. Activating mutations at TKD aspartic acid residue 835 are resistant to pexidartinib-mediated inhibition, however (Smith et al, 2015a, b).
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