Reactome | Drug resistance of FLT3 mutants

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Drug resistance of FLT3 mutants Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
created	[InstanceEdit:9702505] Rothfels, Karen, 2020-09-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9702506
disease	[Disease:1500689] cancer
displayName	Drug resistance of FLT3 mutants
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
eventOf	[Pathway:R-HSA-9682385] FLT3 signaling in disease - Homo sapiens
figure	[Figure:9758323] /figures/ehld/R-HSA-9702506.svg
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-9702605] pexidartinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702620] quizartinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702614] ponatinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702624] sorafenib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702632] sunitinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702636] tandutinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702600] midostaurin-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9703009] tamatinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702581] crenolanib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702577] semaxanib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702998] linifanib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702590] gilteritinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702596] lestaurtinib-resistant FLT3 mutants - Homo sapiens [Pathway:R-HSA-9702569] KW2449-resistant FLT3 mutants - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9683353] Targeting FLT3 mutations in AML: review of current knowledge and evidence [LiteratureReference:9683360] Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least Resistance [LiteratureReference:9695671] Molecular targeting in acute myeloid leukemia [LiteratureReference:9695653] FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions [LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
maxDepth	3
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Drug resistance of FLT3 mutants
normalPathway	[Pathway:R-HSA-9607240] FLT3 Signaling
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9702506
summation	[Summation:9703052] FLT3 is mutated in ~30% of acute myeloid leukemias (AML), wi...

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[Pathway:R-HSA-9682385] FLT3 signaling in disease

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