Reactome | ceritinib-resistant ALK mutants don't bind ceritinib

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ceritinib-resistant ALK mutants don't bind ceritinib Show undefined attributes

authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9700663] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700658
disease	[Disease:1500689] cancer
displayName	ceritinib-resistant ALK mutants don't bind ceritinib
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
entityFunctionalStatus	[EntityFunctionalStatus:9714049] loss_of_function of ceritinib-resistant ALK mutants [plasma membrane]
eventOf	[Pathway:R-HSA-9717323] ceritinib-resistant ALK mutants - Homo sapiens
input	[ChemicalDrug:R-ALL-9699602] ceritinib [cytosol] [DefinedSet:R-HSA-9700553] ceritinib-resistant ALK mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer [LiteratureReference:9713886] Efficacy and Safety of Lorlatinib in Korean Non-Small-Cell Lung Cancer Patients With ALK or ROS1 Rearrangement Whose Disease Failed to Respond to a Previous Tyrosine Kinase Inhibitor [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ceritinib-resistant ALK mutants don't bind ceritinib
normalReaction	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs
releaseDate	2021-06-09
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9700658
summation	[Summation:9714027] The following ALK mutants are resistant to inhibition by cer...

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[Pathway:R-HSA-9717323] ceritinib-resistant ALK mutants

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