Reactome | ceritinib-resistant ALK mutants [plasma membrane]

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ceritinib-resistant ALK mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9700658] ceritinib-resistant ALK mutants don't bind ceritinib - Homo sapiens
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700553
disease	[Disease:1500689] cancer
displayName	ceritinib-resistant ALK mutants [plasma membrane]
hasMember	[Complex:R-HSA-9715309] ALK L1122V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9714056] ALK I1171S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700000] ALK F1174C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699987] ALK F1174L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700005] ALK F1174V dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700520] ALK L1196M dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701834] ALK G1202R dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701827] ALK D1203N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701828] ALK G1269A dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9700317] ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression [LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer [LiteratureReference:9713886] Efficacy and Safety of Lorlatinib in Korean Non-Small-Cell Lung Cancer Patients With ALK or ROS1 Rearrangement Whose Disease Failed to Respond to a Previous Tyrosine Kinase Inhibitor [LiteratureReference:9713944] Multiple Acquired Resistance Mutations of the ALK Tyrosine Kinase Domain after Sequential Use of ALK Inhibitors [LiteratureReference:9700357] Treatment Efficacy and Resistance Mechanisms Using the Second-Generation ALK Inhibitor AP26113 in Human NPM-ALK-Positive Anaplastic Large Cell Lymphoma [LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
maxDepth	3
modified	[InstanceEdit:9757298] Rothfels, Karen, 2021-10-28
name	ceritinib-resistant ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700553

Referrals

(input)	[FailedReaction:R-HSA-9700658] ceritinib-resistant ALK mutants don't bind ceritinib
(diseaseEntity)	[EntityFunctionalStatus:9714049] loss_of_function of ceritinib-resistant ALK mutants [plasma membrane]

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