Reactome | ALK dimer:ligand:type I ALK binding TKI [plasma membrane]

Schema > Complex > Entries

ALK dimer:ligand:type I ALK binding TKI [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9700589] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700592
disease	[Disease:1500689] cancer
displayName	ALK dimer:ligand:type I ALK binding TKI [plasma membrane]
hasComponent	[CandidateSet:R-HSA-9850908] ligand-bound ALK dimer [plasma membrane] [DefinedSet:R-ALL-9699973] type I ALK-binding TKIs [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Mus musculus [Complex:R-RNO-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Rattus norvegicus [Complex:R-CFA-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Canis familiaris [Complex:R-BTA-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Bos taurus [Complex:R-SSC-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Sus scrofa [Complex:R-DRE-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Danio rerio [Complex:R-XTR-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - Gallus gallus
isChimeric	false
maxDepth	6
modified	[InstanceEdit:9850951] Rothfels, Karen, 2023-10-12
name	ALK dimer:ligand:type I ALK binding TKI
negativelyRegulates	[NegativeRegulation:9700650] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'
producedByEvent	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9700592
updateTrackers	[UpdateTracker:9906432] Update Tracker - [Complex:9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - v87:[add_removeHasComponent, modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9906432] Update Tracker - [Complex:9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane] - v87:[add_removeHasComponent, modifyName]
(output)	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs
(regulator)	[NegativeRegulation:9700650] Negative regulation by 'ALK dimer:ligand:type I ALK binding TKI [plasma membrane]'