Reactome | alectinib resistant ALK mutants [plasma membrane]

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alectinib resistant ALK mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9700656] alectinib resistant ALK mutants don't bind alectinib - Homo sapiens
created	[InstanceEdit:9700562] Rothfels, Karen, 2020-09-16
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9700560
disease	[Disease:1500689] cancer
displayName	alectinib resistant ALK mutants [plasma membrane]
hasMember	[Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9714056] ALK I1171S dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700519] ALK I1171T dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700000] ALK F1174C dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715315] ALK V1180L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9700520] ALK L1196M dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701829] ALK L1198F dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9701834] ALK G1202R dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9715310] ALK S1206C dimer [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9700317] ALK F1174V mutation confers sensitivity while ALK I1171 mutation confers resistance to alectinib. The importance of serial biopsy post progression [LiteratureReference:9711845] Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib [LiteratureReference:9713876] Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non-Small-Cell Lung Cancer: Analysis and Literature Review [LiteratureReference:9713917] Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer [LiteratureReference:9713982] Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden [LiteratureReference:9715259] Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib [LiteratureReference:9717278] Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma
maxDepth	3
modified	[InstanceEdit:9717350] Rothfels, Karen, 2021-03-08
name	alectinib resistant ALK mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9700560

Referrals

(input)	[FailedReaction:R-HSA-9700656] alectinib resistant ALK mutants don't bind alectinib
(diseaseEntity)	[EntityFunctionalStatus:9714044] loss_of_function of alectinib resistant ALK mutants [plasma membrane]

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